This OLCC programming example page demonstrates getting a standard InChI code from NCI/CADD can be used to match two SMILES strings using JavaScript .

Press the "test" button to evaluate the JavaScript in the textarea below.
Feel free to modify the JavaScript and press test again.

var smiles1 = "C1=CC=CC=C1O"; var smiles2 = "c1ccccc1O"; var inchi1 = ""; var inchi2 = ""; var checkSmiles = function(d1, d2) { d1 && (inchi1 = d1); d2 && (inchi2 = d2); inchi1 && inchi2 && alert(inchi1==inchi2); } $.ajax({ url:"https://cactus.nci.nih.gov/chemical/structure/" + smiles1+"/stdinchi", success: function(data){checkSmiles(data, null)} }); $.ajax({ url:"https://cactus.nci.nih.gov/chemical/structure/" + smiles2+"/stdinchi", success: function(data){checkSmiles(null, data)} });